Pharmacy Curriculum Outcomes Assessment (PCOA) 2025 – 400 Free Practice Questions to Pass the Exam

Question: 1 / 400

Why should aminoglycoside doses be adjusted for obese patients?

Increased metabolism

Decreased absorption

Significant difference in the total amount of water per kg

Obese patients have a higher total body weight than non-obese patients, which affects the distribution of drugs in the body. The total body water per kilogram is significantly different in an obese patient compared to a non-obese patient. This means that aminoglycoside doses need to be adjusted for obese patients to account for this difference in body composition. Options A, B, and D are incorrect because they do not adequately explain the need for dose adjustment in obese patients. Increased metabolism, decreased absorption, and higher fat solubility may all be factors in drug metabolism, but they do not specifically relate to the difference in total body water per kg for obese patients.

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Higher fat solubility of drugs

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